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MessagePosté le: Mer 4 Mai - 00:47 (2016)    Sujet du message: Download Drug Metabolism Handbook Concepts And Applications Répondre en citant




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Pharm Res (NY) 12: 1722-1726. "Soft Steroids having anti-inflammatory activity". The metabolic intrinsic clearance, CLint,mi, was kept at 0.1 ml/min; the partitioning clearance of drugs, CLd1 and CLd2, was 0.9 ml/min. Abstract/FREE Full Text Allen JD, van Loevezijn A, Lakhai JM, van der Valk M, van Tellingen O, Reid G, Schellens JH, Koomen GJ, and Schinkel AH (2002) Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Moreover, these models do not relate to blood flow, drug partitioning, and the phenomenon of route-dependent intestinal metabolism. CrossRefMedline Zhao YH, Abraham MH, Le J, Hersey A, Luscombe CN, Beck G, Sherborne B, and Cooper I (2002) Rate-limited steps of human oral absorption and QSAR studies. CrossRef Lipka E, Lee ID, Langguth P, Spahn-Langguth H, Mutschler E, and Amidon GL (1995) Celiprolol double-peak occurrence and gastric motility: nonlinear mixed effects modeling of bioavailability data obtained in dogs. Wacher VJ, Salphati L, and Benet LZ (2001) Active secretion and enterocytic drug metabolism barriers to drug absorption. pp.9691000.

Sandy Pang Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada Address correspondence to: Dr. II. ^ a b Bodor, N.; Buchwald, P. (1984). "Androstene Derivatives". Medline Koster AS, Frankhuijzen-Sierevogel AC, and Noordhoek J (1985) Glucuronidation of morphine and six 2-sympathomimetics in isolated rat intestinal epithelial cells. These are exemplified by verapamil (Saitoh and Aungst, 1995; Sandstrm et al., 1998); anticancer drugs such as vincristine, etoposide, daunorubicin, and paclitaxel (Leu and Huang, 1995; Sonnichsen et al., 1995; Nakayama et al., 2000; Chico et al., 2001; Wacher et al., 2001; Abraham et al., 2002); digoxin (Cavet et al., 1996; Greiner et al., 1999); indinavir, the human immunodeficiency virus protease inhibitor (Hochman et al., 2000, 2001; Li et al., 2002); and immunosuppressive agents cyclosporin (Gan et al., 1996; Lown et al., 1997b), tacrolimus (Lampen et al., 1995; Hashimoto et al., 1998; Hashida et al., 2001), and sirolimus (Lampen et al., 1998; Paine et al., 2002). 2. Accepted July 14, 2003.

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